In a new study, published in Cell, researchers describe a newfound mechanism for creating proteins in a giant DNA virus, ...

tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...

Premature termination of transcription influences ribosomal RNA output and RNA polymerase I drug sensitivity, revealing a mechanism of resistance to transcription-targeting chemotherapy.

From vaccines and diagnostics to emerging gene-based therapies, RNA molecules are now central to modern medicine. But as ...

Researchers developed C28, an engineered polymerase that efficiently synthesizes RNA at near-natural speeds with high accuracy. Created through directed evolution, the enzyme also performs reverse ...

New findings from Karolinska Institutet reveal how the gene HNRNPU coordinates several fundamental molecular processes during ...

Both UAP56 and URH49, which form essential complexes for mRNA export, evolved from a common ancestral gene. However, the distinct roles that these complexes play, as well as the structural differences ...

EXPORT MECHANISM: The tRNA must mature inside the nucleus before export. tRNAs are aminoacylated, and only tRNAs charged with an amino acid are exported efficiently. Export occurs when the tRNA is ...

CD Bioparticles launches specialized RNA Synthesis services for researchers to develop next-generation mRNA vaccines, gene therapies, and RNA-based therapeutics.

A novel study uncovers how a subtle chemical tweak transforms the naturally occurring phytotoxin into a powerful molecular glue, 12-deoxyfusicoccin (12-dFC), that locks 14-3-3 proteins onto the ...