Although the α-helical hairpin extensions are reminiscent of a coiled coil topology, thorough inspection reveals that just a few residues exhibit the prototypic 'knobs into holes' pattern 13.
The biogenesis of integral outer-membrane proteins (OMPs) in Gram-negative bacteria requires molecular chaperones that prevent the aggregation of OMP polypeptides in the aqueous periplasmic space. How ...
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