Antimicrobial resistance (AMR) is diminishing the effectiveness of existing antibiotics and intensifying the need for discovery pipelines that are both ...

Part I. Introduction: Bioinformatician's primers. 1. Introduction to genome biology and diversity / Noor Youssef, Aidan Budd, and Joseph P. Bielawski ; 2. Probability, statistics, and computational ...

A new genomic method has enabled multiple people with rare conditions to receive diagnoses that were previously unattainable by identifying complex structural genetic changes that are often missed by ...

Understanding human gene function in living organisms has long been hampered by fundamental differences between species. Although mice share most protein-coding genes with humans, their regulatory ...

Humanized mouse models are essential for investigating human gene function; however, the complete replacement of mouse genes with entire human sequences has posed significant technical challenges.