The funding, part of a new ARPA-H bioprinting initiative, aims to create transplant-ready organs—potentially within ...

Traditional animal models and simplified cell cultures often fail to capture human biology, limiting progress in biomedical research and drug development. Emerging microfluidic "Organ-on-Chip" ...

A frequently reported fact in the drug discovery and development industry is that approximately 90 % of drug candidates reaching clinical trials fail, with even higher amounts discarded before ...

The models can be used to plan surgeries and in the future could be used to help trial new drugs. A healthy heart beats at a steady rate, between 60 and 100 times a minute. That’s not the case for all ...

Overcoming acquired treatment resistance is one of the major challenges in the fight against cancer. While combination therapies hold promise, their toxicity to healthy tissue remains a major hurdle.

A lot happens in the first month of human embryo development as a single cell morphs into multitudes. Yet despite its significance, this period is basically a “black box” to researchers, says stem ...

For decades, animal models have been the gold standard for preclinical testing of potential drugs. Yet, even the best animal models are not perfect. For example, small rodent species with engrafted ...

Wearing blue rubber gloves, Molly Dobrow reached into a metal vat of diluted sodium hydroxide and pulled out two dripping-wet models of human organs: a heart and a set of lungs. Made of Elastico, a ...

Absorption, distribution, metabolism, and excretion (ADME) are four main processes that demonstrate how a drug behaves after being administered. Therefore, ADME is key in defining a compound’s ...