A team of scientists has uncovered a critical mechanism that could pave the way for safer and more effective obesity ...

Scientists have discovered a brain signaling pathway that eliminates body fat without reducing food intake by targeting ...

Leptin is a cell-signalling hormone vital in the regulation of appetite, food intake and body weight. Studies have shown that an absence of leptin in the body or leptin resistance can lead to ...

"Leptin resistance is a major barrier to treating obesity," senior author Işın Çakır said in a Pitt news release via UPMC.

OBJECTIVE: To examine the determinants of plasma leptin levels and leptin resistance in a sample of extremely obese subjects and their relatives. DESIGN and METHOD: We obtained plasma leptin values on ...

Celastrol's potent anti-obesity effects were widely reported in 2015. Derived from the roots of the thunder god vine, the drug curbed food intake in obese mice by nearly 80 percent, producing up to a ...

Plasma leptin levels were linked with Alzheimer's disease PET pathology in cognitively unimpaired older adults in Korea. Lower baseline leptin was associated with a greater increase in tau over 2 ...

Leptin plays an important role in regulating appetite and body weight. Leptin binds to a form of leptin receptor present in the cells of the hypothalamus. This stimulates an intracellular signalling ...

Twenty years after the hormone leptin was found to regulate metabolism, appetite, and weight through brain cells called neurons, Yale School of Medicine researchers have found that the hormone also ...

Figure 1: Body weight gain, food intake and plasma insulin and leptin levels in chow-fed mutant mice and wild-type littermates. Figure 4: a and b, Measures of glucose homeostasis in mutant mice (M) ...

In cattle, this gene and the hormone it produces regulates metabolism, fat deposition, and affects reproduction.