We use both in vitro and in vivo approaches to examine the roles of Eg5 (kinesin-related protein), cytoplasmic dynein, and dynactin in the organization of the microtubules and the localization of NuMA ...

We have studied cytoskeletal architectures of isolated mitotic apparatus from sea urchin eggs using quick-freeze, deep-etch electron microscopy. This method revealed the existence of an extensive ...

Proper chromosome segregation into two future daughter cells requires the mitotic spindle to elongate in anaphase. However, although some candidate proteins are implicated in this process, the ...

Many millions of times per day, football-shaped structures called mitotic spindles form within the body's cells as they prepare to divide. The process is routine but mysterious, as the micro-mechanics ...

Zachary Gergely, Michele Jones, Bojun Zhou, Cai Cash, J. Richard McIntosh, and Meredith D. Betterton (2023). Distinct regions of the kinesin-5 C-terminal tail are essential for mitotic spindle midzone ...

For a living cell to divide successfully, each daughter cell must inherit the correct genetic material. In eukaryotes, segregation of duplicated chromosomes is performed by the mitotic spindle, a ...

No significant financial relationships to disclose. This is an ASCO Meeting Abstract from the 2007 ASCO Annual Meeting. This abstract does not include a full text component.