Super-enhancers (SEs) are large clusters of transcriptional regulatory elements that drive oncogene expression, maintain ...

Case Western Reserve University researchers have taken a dramatic step forward in the fight against cancer—all by starting at the very beginning. Scientists led by School of Medicine Professor Mark W.

Northwestern Medicine scientists have discovered that a specific long non-coding RNA activates oncogenic signaling pathways in prostate cancer cells and drives tumor progression, underscoring its ...

Neuroblastoma can be a particularly insidious cancer. In about half of all cases, tumors regress, even without therapy. In the other half, tumors grow very quickly. These tumors often respond well to ...

Extrachromosomal DNAs (ecDNAs) are circular DNA structures located in the nuclei of cells outside chromosomes. They were originally discovered in chromosome spreads of cells obtained from embryonal ...

Perioperative therapy has become a critical component in the management of resectable non–small cell lung cancer (NSCLC), particularly in the era of precision medicine. Although molecular testing is ...

Tumor-suppressive miRNAs inhibit oncogenic pathways, preventing cancer progression, while oncogenic miRNAs promote tumor growth by targeting tumor suppressor genes. miRNA, microRNA. Lung cancer (LC) ...

Pancreatic cancer is notoriously hard to treat, often resisting therapies that target its most common mutations. Researchers have now uncovered a hidden three-part loop that fuels tumor growth, ...

Boundless Bio (Nasdaq: BOLD), a clinical-stage oncology company interrogating extrachromosomal DNA (ecDNA) biology to deliver transformative therapies to patients with previously intractable oncogene ...