・A mouse model of tuberous sclerosis complex (TSC) had abnormal dendritic spine morphology and neuronal dysfunction. These abnormalities were rescued by the administration of a Rheb inhibitor. ・This ...
The Tsc1/2 complex inactivates Rheb. A mutation in Tsc2 results in Rheb activation, inducing neuron morphological defects and dysfunctions. These abnormalities promote memory impairment in TSC mice.
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