Neurturin (NTN), a member of glial cell line-derived neurotrophic factor (GDNF) family, is known as an important neurotrophic factor for penis-projecting neurons. We recently demonstrated significant ...
The design of highly defective herpes simplex virus (HSV) vectors for transgene expression in nonneuronal cells in the absence of toxic viral-gene activity has been elusive. Here, we report that ...
Micturition depends on the coordinated activity of the urinary bladder and external urethral sphincter. 1 However, spinal cord injury (SCI) rostral to the lumbosacral level, which impairs voluntary ...
Oncolytic herpes simplex virus type I (HSV-1) vectors are promising therapeutic agents for cancer. Their efficacy depends on the extent of both intratumoral viral replication and induction of a host ...
The FDA granted the first drug approval for dystrophic epidermolysis bullosa (DEB), a topical gene therapy that treats the blistering wounds it causes, the agency announced Friday. The herpes-simplex ...
Boosting of cellular and humoral immune responses to HPV16/18 antigens by VGX-3100: A follow-on phase I trial. A first-in-class, first-in-human phase I study of enadenotucirev, an oncolytic Ad11/Ad3 ...
New Rochelle, NY, March 14, 2013—Severe chronic pain associated with conditions such as bladder pain syndrome/interstitial cystitis often require the use of opioid medication, with the risk of ...
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