At the heart of Toti-N-Seq lies an engineered protein, Stv-Fg, derived from modifying the natural glycan-binding protein Fbs1. This fusion protein binds non-selectively to all N-glycan types, enabling ...

This integrated approach, combining histological analysis and single-nucleus RNA sequencing, revealed that the senescence and depletion of nucleus pulposus progenitor cells (NPPCs) represent ...

The rapid advancement of single-cell and single-nucleus RNA sequencing (sc/snRNA-seq) has opened unprecedented windows into cellular diversity, yet existing methods for multiplexing samples struggle ...

Using single-nuclei RNA sequencing (snRNA-seq), scientists from Mass General Brigham, SUNY Upstate Medical University, and elsewhere have identified specific brain cell types in the hippocampus that ...

Using advanced single-nuclei RNA sequencing (snRNA-seq) and a widely used preclinical model for Alzheimer's disease, researchers from Mass General Brigham and collaborators at SUNY Upstate Medical ...

Scientists in the laboratory of Rendong Yang, Ph.D., associate professor of Urology, have developed a new large language model that can interpret transcriptomic data in cancer cell lines more ...

Capturing spatial information is essential to elucidate how cells function and interact within their native tissue environment. However, the initial spatial transcriptomics techniques have several ...