Brock Purdy threw a career-high five touchdown passes and Dee Winters returned an interception 74 yards for a score to lead the San Francisco 49ers to a 48-27 victory at Indianapolis

The 49ers' win over the Colts had big playoff implications in the AFC. Here are our takeaways from Monday night.

By virtue of the Indianapolis Colts losing to the San Francisco 49ers on Monday night, the Chargers secured a playoff berth, and the division title and top seed in the AFC are still in play.

Brock Purdy threw five touchdown passes as the 49ers rolled to a 48-27 win over the Colts on Monday Night Football. Joe Montana was the last 49ers quarterback to throw five touchdowns when he did it in 1990.

Brock Purdy and the San Francisco 49ers earned a statement 48–27 road win over Philip Rivers and the Indianapolis Colts on Monday Night Football, as both quarterbacks put on an entertaining aerial showcase.

Indianapolis Colts quarterback Philip Rivers discusses the team's 48-27 loss to the San Francisco 49ers. Clark Wade. Watch Next

The Colts' Monday night loss to the 49ers is the Bills' gain. And the Jaguars'. And the Chargers'. All three teams have officially clinched playoff berths, as a result of the 49ers beating Indianapolis,

One of the hottest teams in the NFL, the San Francisco 49ers defeated the Indianapolis Colts 48-27 on "Monday Night Football." 49ers quarterback Brock Purdy threw for 295 yards and a career-high five touchdowns,