Surface model of SpCas9–reverse transcriptase–pegRNA–target DNA complex. The prime editor, composed of a SpCas9 and a reverse transcriptase, reverse transcribes template sequence in pegRNA, resulting ...

Assessments of DNA misrepair, and the resulting effects on the structural integrity of the genome, are critical for evaluating the safety of cell and gene therapy applications. Most genome editing ...

Scientists have revealed how Fanzor2's divergence from bacterial ancestors may make it a useful tool for future genomic engineering endeavors. A revolution in biomedicine is currently underway, driven ...

Researchers unveil a chemistry playbook to turn stubborn MAX phases into tunable 2D materials, blending MXene and dichalcogenide traits for energy storage and catalysis. Structural editing strategy ...

AI-assisted structural predictions and alignments establishes a new protein classification and functional mining method, further enabling the discovery of a suite of single and double-strand cytidine ...