Adopting a Quality by Design (QbD) approach for wet granulation requires manufacturers to comprehend the correlation between process variables, such as powder characteristics and equipment ...

We try to use previous experience to develop the optimal granulation process for each new ingredient, but we sometimes get it wrong. Many times, we?ve taken materials from the granulator only to find ...

Powders are widely used in pharmaceuticals as active ingredients or excipients in formulations. As a result, several production processes are used for handling powders: wet and dry granulation, ...

Dry granulation creates granules by roller compaction of the powder blend with low pressures. The compacted material is then broken and sized gently to produce agglomerates. This process is often used ...

In dry granulation, powders bind because of the application of mechanical stress. As particles are forced to be within closer proximity, entrained air is forced out, bulk density increases, and a ...