Normal, regulated growth of skeletal bones is a crucial part of the growth of mammals. This is a complex process involving the growth of cartilaginous cells or chondrocytes, their transformation into ...

Loss of Dnmt1 disrupted normal DNA methylation in chondrocytes, leading to increased expression of genes involved in cellular energy metabolism. As a result, metabolic abnormalities occurred, ...

In the physiological condition of skeletogenesis (left), SSCs maintain a quiescent state for orderly differentiation which is regulated by the epigenetic signature. Especially at this state, ...