Scientists from King's College London have found that an immune protein known for its protection against infections plays an ...

Researchers at King's College London have discovered that an immune protein best known for protecting the body against infection also plays an ...

Researchers at King's College London have discovered that an immune protein best known for protecting the body against ...

Bone health relies on a balance between osteoblasts (builders) and osteoclasts (recyclers). Peak bone mass occurs in early adulthood; deficiencies during this window amplify fracture risks later in ...

Spontaneous osteoclastogenesis, a phenomenon characterized by the unregulated differentiation and activation of osteoclasts in the absence of exogenous stimulatory factors, plays a central role in ...

Rather than completely blocking all downstream signals, the peptide developed in this study focuses on inhibiting the activation of p38-MAPK. This is enough to downregulate the development of mature ...

A recent study identifies Neural EGFL-like 2 (NELL2), a secreted protein, as a key regulator of bone homeostasis, offering potential therapeutic applications for osteoporosis. NELL2 promotes ...

Healthy bone depends on the proper function of osteoclasts, the cells that break down bone during normal remodeling. Using mouse models, we uncover an unexpected role for the immune surveillance ...

ABSTRACT: With the aging of the global population, bone degenerative diseases (such as osteoporosis) have become a major threat to the health of the elderly. The immune system plays a key role in the ...

In 1997, investigators isolated a secreted glycoprotein that blocked osteoclast differentiation from precursor cells, prevented osteoporosis (decreased bone mass) when administered to ovariectomized ...