Axonal Transport Not Bothered by Tau Elevation In Vivo
Feb 27, 2008 · Measuring axonal transport in the optic nerve of mice that either overexpress the long form of human tau, or have no tau at all, these investigators detect no alteration whatsoever in the …
Neuropathogenic forms of huntingtin and androgen receptor inhibit …
Both papers conclude that impaired axonal transport plays a significant role in mechanisms underlying neurodegeneration. Significantly, the views proposed in these papers complement and extend the …
Axonal transport deficits and degeneration can evolve independently in ...
Abnormal axonal transport has been frequently brought into discussion as a possible cause of the neuronal pathology, especially because the task of transporting organelles, proteins, and mRNAs to …
Axonal transport of late endosomes and amphisomes is selectively ...
May 5, 2022 · In this new paper, the group further investigated the molecular mechanism underling axon degeneration mediated by impaired acidification of the lysosomal organelles, and its potential relation …
Abeta oligomers cause localized Ca (2+) elevation ... - ALZFORUM
Sep 16, 2010 · This manuscript is very interesting. Mandelkow’s group basically has studied many aspects of tau, such as the structure, aggregation mechanism, phosphorylation kinases, and …
Disruption of dynein/dynactin inhibits axonal transport in motor ...
Jun 11, 2002 · However, the established role for dynein and dynactin in axonal transport, both fast retrograde transport and the net slow anterograde transport of neurofilaments, suggest that …
Presenilin Mutations Stall Endosomal Transport, Swell Axons
May 5, 2022 · LE acidification and axonal transport appeared normal in cortical slices from 6-month-old mice, but as they got older, axonal transport declined. In cortical slices from 13-month-old mice, LEs …
HDAC6 inhibition reverses axonal transport defects in motor neurons ...
Oct 27, 2017 · The issue of axonal transport in the context of ALS is relevant given the extreme polarization of motor neurons. Even subtle defects in transport would affect the delivery of cargo to …
Neurotrophic factors in Alzheimer's disease: role of axonal transport ...
Schindowski K, Belarbi K, Buée L. Neurotrophic factors in Alzheimer's disease: role of axonal transport. Genes Brain Behav. 2008 Feb;7 Suppl 1:43-56. PubMed.
Mitochondrial Gridlock—Syntaphilin Puts Brakes on Axonal Transport
Jan 23, 2008 · To test if that relationship might affect mitochondrial transport, Kang and colleagues observed the organelles with time-lapse confocal microscopy. They labeled mitochondria with red …