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Anencephaly – A Neural Tube Defect Anencephaly is a severe, lethal congenital anomaly where most of the brain and skull vault fail to develop. The cerebral hemispheres and overlying skull bones are absent, leaving only the brainstem and rudimentary neural tissue exposed. Key facts every nurse/midwife must know: - Occurs in ~1:1000 pregnancies in most populations (higher where folic acid fortification is low) - Diagnosed by antenatal ultrasound as early as 11–14 weeks (“frog-eye” sign, no calvari
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